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Just like other opioids, a perhaps severe adverse drug reaction is respiratory despair. This melancholy is dose-related and is particularly a mechanism for the doubtless deadly implications of overdose.Though acquiring no narcotic effects of its personal, the significant opioid precursor thebaine differs from codeine only slightly in construction.

The usual precautions are indicated for severely depressed people or those in whom There's any proof of latent depression or stress connected with depression, significantly the recognition that suicidal tendencies may very well be present and protective steps may be needed.It might be used in people with open-angle glaucoma who are obtaining accept